|
KMID : 0603520030080030173
|
|
Journal of Korean Association of Cancer Prevention
2003 Volume.8 No. 3 p.173 ~ p.180
|
|
|
Peroxynitrite(ONOO^(-)) Scavenging Activity of Caffeic Acid
|
|
Lee Ji-Young
Soung Do-Yu
No Jae-Kyung
Kim You-Jung
Je Jeong-Hwan
Kim Min-Sun
Choi Jae-Sue
Chung Hae-Young
Lee Kyung-Hee
|
|
|
Abstract
|
|
|
|
Peroxynitrite (ONOO) is produced! by the reaction of superoxide (02) with nitric oxide (NO). ONOO is a powerful oxidant that can cause damages of proteins, lipids, and DNA through more subtle action mechanism, which is called the process of nitration and oxidation. Nitrotyrosine has served as a fingerprint for ONOO mediated damage of cellular proteins in a variety of pathological conditions. Because the body lacks endogenous defense components against ONOO - induced protein modifications, ONOO scavengers should be supplemented. In the present study, caffeic acid showed evidence of scavenger for ONOO -. A dihydroxyl group and a double bond seem to be essential structure requirements. The data from the experiments confirmed a protective effect of caffeic acid on bovine serum albumin (BSA) and low-density lipoprotein (LDL) against ONOO . Further, caffeic aicd was found to protect tert-butyl hydroperoxide (t-BHP)-mediated ROS generation in vascular endothelial cells. The present study demonstrated that caffeic acid with hydroxyl groups and double bonds exerts an anti-nitration effect by scavenging ONOO through electron donation.
|
|
|
KEYWORD
|
|
|
Caffeic acid, Peroxynitrite(ONOO^(-)), Scavenger, Nitration
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|